Daan Frenkel (born 1948, Amsterdam) is a Dutch computational physicist.
Frenkel has carried out the largest part of his research at the FOM institute AMOLF in Amsterdam where he has been employed since 1987. Professor Frenkel is one of the select foreign members of the British Royal Society and has been awarded the title of Rothschild Professor at the University of Cambridge. He is also a recipient of the Aneesur Rahman Prize from the American Physical Society which may be considered as the Nobel prize equivalent in computational physics. In 2001 he was awarded the Spinozapremie, also known as the ´Dutch Nobel prize´. Frenkel has co-authored ´Understanding Molecular Simulation´ which has grown into a handbook used worldwide by aspiring computational physicists. Currently he is a professor at the universities of Amsterdam, Utrecht, Beijing and Cambridge.